I have rheumatoid arthritis which has been actively flaring through this pregnancy. I muddled through the first trimester with Tylenol, but by midway through the pregnancy the pain and immobility were so bad I was being given Tylenol with codeine, and even morphine. Finally got into my rheumatologist, who has me on prednisone and sulfasalazine. The combo is keeping my symptoms manageable, and they are considered safe for pregnancy. I do get ultrasounds every two weeks to monitor baby's growth, fluid levels, and placenta health, but all is good so far (just shy of 38weeks now).